NQCP Friday Life in Quantum - David E. Gloriam
Professor David E. Gloriam will give a talk with the title: Data-driven drug-receptor discovery
Abstract: Over one-third of approved drugs act G protein-coupled receptors (GPCRs) (1). This important drug target family has an online field hub, GPCRdb (2) which has become an indispensable infrastructure for tens of thousands of researchers. In addition to reference data, this web resource provides highly accessible tools for data analysis and data-driven experiment design. The talk will also give examples of how the development of data- and ML-driven drug design methods to discover small molecule and peptide lead ligands.
References
- Hauser, A.S., Attwood, M.M., Rask-Andersen, M., Schioth, H.B. and Gloriam, D.E. (2017) Trends in GPCR drug discovery: new agents, targets and indications. Nat. Rev. Drug Discov., 16, 829-842.
- Kooistra, A.J., Mordalski, S., Pandy-Szekeres, G., Esguerra, M., Mamyrbekov, A., Munk, C., Keseru, G.M. and Gloriam, D.E. (2021) GPCRdb in 2021: integrating GPCR sequence, structure and function. Nucleic Acids Res., 49, D335-D343.
After the talk there will be exciting discussions, networking, and refreshments in Fb7.